{"status":"OK","msg":"Details loaded!","presentation":{"id":119,"title":"ANALYSIS OF IRON, COPPER AND ZINC IN PROSTATE CELL AFTER ZINC TREATMENT FOR PROSTATE DISEASES USING SYNCHROTRON X-RAY MICROFLUORESCENCE","abstract":"Synchrotron Micro X-Ray Fluorescence (\u00b5SRXRF) is a non-destructive technique very often used in biological investigations to obtain information regarding the distribution of elements in tissue and cell samples. Diseases of the prostate are very frequent in men over 40 years of age. Prostate cancer and benign prostatic hyperplasia (BPH) represents, worldwide, a significant risk in terms of morbidity and mortality. In this context, the aim of this work was to investigate the distribution of Fe, Cu and Cu\/Zn using synchrotron X-ray microfluorescence (SR\u00b5XRF) in cell spheroids in benign prostate hyperplasia (BPH) and prostate cancer (DU145) supplemented with Zinc and to analyze the influence on intensity of Fe, Cu and Cu\/Zn after Zinc supplementation. The SR\u00b5XRF measurements were performed in standard geometry of 45\u00ba incidence, exciting with a white beam and using an optical capillary with 20 \u03bcm diameter collimation in the XRF beam line at the Synchrotron Light National Laboratory (Campinas, Brazil). The results showed non-uniform distribution of Fe and Cu in all the spheroids analyzed. It was possible observed that intensity of Fe, Cu and Cu\/Zn were changed with the Zn supplementation. Therefore, the Zn supplementation changes the metabolic of prostate cell.","keywords":"Micro X-Ray Fluorescence; Synchrotron radiation; Trace elements, Prostate; Cancer","status":"active","sarx_st":"accepted","user_id":191,"created_at":"2016-07-11 18:50:53","updated_at":"2016-08-20 12:33:26","filename":"Abstract_(SARX2016)_Leitao.pdf","mode":"oral","sarx_code":"22_O-XRF","poster_group":null,"file":"22f1630ddfe132b20c8151d3c8c67acd.pdf","author":"Roberta Gama Leit\u00e3o","affiliation":"Doctor \/<\/b> UERJ \/<\/b> Brasil","user":{"id":191,"name":"Roberta Gama Leit\u00e3o","degree":"Doctor","email":"roberta.leitao@uerj.br","username":"roberta.leitao@uerj.br","confirmed":1,"confirmation_code":null,"created_at":"2016-07-04 10:44:00","updated_at":"2016-07-04 11:25:43","sarx":1,"affiliation":"UERJ","address":"R. S\u00e3o Francisco Xavier, 524","zipcode":"20550-013","state":"Rio de Janeiro","phone":"+5521988657348","fax":null,"city":"Rio de Janeiro ","country":"Brasil","status":"active","is_admin":0,"category":"student","school":0,"icdd":0}}}