{"status":"OK","msg":"Details loaded!","presentation":{"id":17,"title":"STRUCTURE OF NEVIRAPINE CO-CRYSTAL USING SINGLE CRYSTAL X-RAY DIFFRACTION AND SOLID STATE NMR SPECTROCOPY","abstract":"The antiretroviral drug Nevirapine (NVP) (11-Cyclo-propyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-\r\nb:2\u2019,3\u2019-e][1,4]diazepin-6-one) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of\r\nHIV-1 infection. It is a class II drug according the Biopharmaceutics Classification System (BSC)1,\r\nexhibiting low solubility and high permeability. To increase the drug dissolution and its bioavailability,\r\nthe different preparation methods with crystal modification such as co-crystals were studied. Co-crystals\r\nare multicomponent crystalline solids which have different drug molecules or a drug and a non-volatile\r\nsubstance in its structure. NVP molecule has a conformationally rigid amide group that allows a co-crystal\r\nformation with soluble carboxylic acids or amide co-formers2. Caira et al. reported the crystal structure\r\nand solid state properties of several NVP co-crystals2. We prepared different co-crystals of NVP and there\r\nwere identified using their crystal structure Caira published data. The only case where we observed\r\ndifferences was for NVP-salicylic acid (NVP-AS). Our data presented different reflections in comparison\r\nwith reported data. Therefore, the goal of this work was to determinate the crystal structure of NVP-AS\r\nusing single crystal X-ray diffraction in combination with solid state NMR spectroscopy in order to\r\nconfirm our crystal structure results.\r\n1 Lindenberga, M.; Koppb, S.; Dressmana, J. B. European Journ. of Pharm. and Biopharmaceutics. 2004, 265-278.\r\n2 Caira, M.R. et. al. CrystEngComm. 2012, 17-23.\r\n\r\nAcknowledgement: We are grateful for the financial support of CAPES for this project.","keywords":"X-Ray Diffraction; ssNMR spectroscopy; co-crystal; Nevirapina","status":"active","sarx_st":"accepted","user_id":40,"created_at":"2016-04-06 16:19:29","updated_at":"2016-08-20 12:44:21","filename":"Abstract2FSARX16.pdf","mode":"oral","sarx_code":"18_O-XRD","poster_group":null,"file":"8c22a235a0a1100c10b7398ba381f902.pdf","author":"Silvia Lucia Cuffini","affiliation":"Ph.D \/<\/b> UNIFESP \/<\/b> Brazil ","user":{"id":40,"name":"Silvia Lucia Cuffini","degree":"Ph.D ","email":"scuffini@gmail.com","username":"scuffini@gmail.com","confirmed":0,"confirmation_code":"d32Q8qLdwvnxDUrbEKerI2IkzM9dsG","created_at":"2016-04-04 03:18:50","updated_at":"2016-04-04 03:19:16","sarx":1,"affiliation":"UNIFESP","address":"Rua Talim 330","zipcode":"12231-280 ","state":"S\u00e3o Paulo ","phone":"12982051100","fax":null,"city":"S\u00e3o Jose dos Campos ","country":"Brazil ","status":"active","is_admin":0,"category":"professor","school":0,"icdd":0}}}