{"status":"OK","msg":"Details loaded!","presentation":{"id":26,"title":"ANOMALOUS DISSOLUTION BEHAVIOR OF SAQUINAVIR MESYLATE IN SODIUM LAURYL SULPHATE","abstract":"Saquinavir (SQV) is an important protease inhibitor used for AIDS\/HIV antiretroviral therapy. It is commercialized as mesylate salt (SQVM) and classified as belonging to class IV (low permeability and solubility). The dissolution properties were investigated by SQVM in the medium containing the anionic surfactant Sodium Lauryl Sulphate (SLS). It was expected that the electrostatic interactions between the anions of SLS and the cationic drug species could cause a decrease in the repulsive forces of the head groups of the surfactant molecules leading to enhanced solubilization. However, for the SQVM profile in the anionic surfactant medium the result obtained was contradictory. Therefore, the aim of this study was to explain the anomalous dissolution behavior of SQVM in SLS medium through a structural analysis. The anionic portion of SLS remaining molecules interact with the cationic species of SQV to form an insoluble salt which precipitates out (Figure 1) and results in desolubilization phenomenon. Through crystallographic investigation it was possible to demonstrate the crystallization of SQVM with SLS. Therefore, SLS is not an appropriate dissolution medium to analyse the dissolution properties of SQVM.\r\n \r\n Figure 1 \u2013 (A) Dissolution profile of SQVM raw material and (B) Turbidity of SQVM in SLS 0.25% medium\r\n","keywords":"Saquinavir Mesylate; Dissolution Properties; Sodium Lauryl Sulphate; Crystallography","status":"active","sarx_st":"accepted","user_id":44,"created_at":"2016-04-07 01:12:03","updated_at":"2016-08-20 12:07:24","filename":"Abstract SARX 2016.doc","mode":"oral","sarx_code":"01_O-XRD","poster_group":null,"file":"18ed4aeadac8dd915864d2424098818d.doc","author":"Cinira Fandaruff","affiliation":"Doutoranda \/<\/b> Universidade Federal de Santa Catarina \/<\/b> Brasil","user":{"id":44,"name":"Cinira Fandaruff","degree":"Doutoranda","email":"cinira_fandaruff@hotmail.com","username":"cinira_fandaruff@hotmail.com","confirmed":0,"confirmation_code":"WuqLkwGarRX7eyPuj62UIBWdxDDNMO","created_at":"2016-04-04 18:20:14","updated_at":"2016-04-07 01:24:56","sarx":1,"affiliation":"Universidade Federal de Santa Catarina","address":"Trindade ","zipcode":"88040900","state":"Santa Catarina","phone":"47 96057453","fax":null,"city":"Florian\u00f3polis","country":"Brasil","status":"active","is_admin":0,"category":"professor","school":0,"icdd":0}}}