{"status":"OK","msg":"Details loaded!","presentation":{"id":5,"title":"X-RAY DIFFRACTION STUDY OF THIOCOLCHICOSIDE ETHANOL SOLVATE HYDRATE","abstract":"In the pharmaceutical industry is important characterize the active pharmaceutical ingredients (APIs) involved in the manufacture of a drug. It is well-known that a number of physicochemical properties of the APIs depend on the structural characteristics in the solid state. Thiocolchicoside is an active pharmaceutical ingredient used as a muscle relaxant. The only crystal structure thiocolchicoside-related reported in the Cambridge Structural Database corresponds to an ethanol solvate hydrate (Refcode: THCLCS). However, the hydrogen atoms information and intermolecular interactions is not reported. Yellow prism crystals were obtained from an ethanol\/water solution at room temperature. Integration and reduction of the single diffraction data produced an orthorhombic cell with space group P212121 (No. 19) and parameters a= 9.8311(7) \u00c5, b= 12.0923(8) \u00c5, c= 28.180(2) \u00c5, V= 3350.1(4) \u00c53, similar to THCLCS. The present X-ray diffraction study consists in a crystal structure, hydrogen bonding and CH...\u03c0 interactions analysis which play an important role in the crystal packing and have not been reported previously for this material.","keywords":"X-Ray diffraction; thiocolchicoside; polymorphism","status":"active","sarx_st":"accepted","user_id":33,"created_at":"2016-04-01 02:29:56","updated_at":"2016-08-20 12:43:27","filename":"Abstract (SARX2016)_RT.doc.docx","mode":"oral","sarx_code":"16_O-XRD","poster_group":null,"file":"b280c2dffb27762b9a328102cf6df7a4.docx","author":"Robert Toro","affiliation":"Dr. \/<\/b> Universidaad Industrial de Santander \/<\/b> Colombia","user":{"id":33,"name":"Robert Toro","degree":"Dr.","email":"toro.robert@gmail.com","username":"toro.robert@gmail.com","confirmed":0,"confirmation_code":"88nBnbkMMt5VCdu7SdoU6mufJD6xnf","created_at":"2016-03-28 20:38:11","updated_at":"2016-04-01 02:39:03","sarx":0,"affiliation":"Universidaad Industrial de Santander","address":"Caller 8N, Resiencia Camelot, Torre 2, apartamento 402","zipcode":"681011","state":"Santander","phone":"+573158576584","fax":null,"city":"Pie de Cuesta","country":"Colombia","status":"active","is_admin":0,"category":"professor","school":0,"icdd":0}}}